Biomarker is the indicator   that can be accurately measured as signal of normal biological functioning, pathogenic paths or a drug response to a therapeutic drug mediation. Biomarkers are usually in molecular form. Biomarkers take place in various body functions, including disease diagnosis and prognosis, prediction and calculation of treatment response, and safety estimation. These  Biomarkers are  being developed and confirmed to be used in drug  development, and to support approval of drug products.